Micotherapy Linfo AVD Reform

Food supplement containing organically grown Polyporus umbellatus, bromelain and plant extracts.


Health benefits:
Containing organically-grown Polyporus umbellatus, bromelain and plant extracts, Micotherapy Linfo promotes the function of the microcirculation and the drainage of body fluids, thereby reducing water retention.


Properties:
The lymphatic system consists of a complex system of vessels, very similar to the venous and arterial circulatory systems. Unlike blood, lymph is not propelled by the activity of the heart, rather flows through the vessels due to movement. It moves throughout the body and originates from a fine network of lymphatic capillaries located in the extracellular space; along the way, lymph nodes appear at regular intervals, like a filtration system.

A properly functioning lymphatic system ensures adequate “cleansing” of the extracellular matrix immersed in the interstitial fluid, in order to prevent cellular intoxication. As the extracellular matrix is a primary bioregulatory system, it is essential that it remains ‘clean’ to ensure communication between cells, systems and organs and consequently maintain the body’s homeostasis.

The remedies contained in this formulation have a strong tropism for the lymphatic and venous systems, and promote the drainage of toxins from the body’s tissues. They therefore help to reduce situations of lymphatic and venous stasis, swelling, oedema and water retention.


Ingredients:

  • Polyporus umbellatus whole mushroom
  • Centella dry extract (tit. at 40% in Asiaticoside)
  • Bromelain (tit. at min. 2400 GDU/g)
  • Melilot dry extract (tit. at 20% in coumarins)

Properties of the ingredients:

  • Polyporus umbellatus: is a fungus with a diuretic action that is particularly effective in the presence of water retention, oedema and urination problems. Studies have shown that Polyporus does not cause any side effects as it allows the elimination of sodium and chlorine but retains potassium. Useful in the presence of lymphatic stasis
  • Centella dry extract: improves venous circulation by stimulating the fibroblasts, cells that regenerate collagen, a substance that is essential to the health of many body tissues. Useful for improving situations of peripheral venous insufficiency, cramps, haemorrhoids and cellulite
  • Bromelain extracted from pineapple stems: proteolytic, antithrombotic and anti-inflammatory action. Useful for alleviating mild soft tissue inflammation and in the treatment of localised inflammatory conditions, particularly in the presence of oedema
  • Melilot dry extract (tit. at 20% in coumarins): it reduces vein wall permeability and increases capillary resistance. It improves venous return and lymphatic circulation, presenting anti-inflammatory and anti-oedematous effects. Useful in the presence of haemorrhoids, varices, thrombophlebitis and lymphatic stasis

Directions:
2 capsules twice per day, preferably not immediately before or after or during meals


Pack:
90 capsules


Notes:
store in a cool, dry place.


Listed in the food supplement register: code 62491


Paraph. code: A923582136


AVERAGE CONTENT OF CHARACTERISING INGREDIENTS PER DAILY DOSE (4 CAPSULES)
Polyporus umbellatus sporophorum 1188 mg
Centella dry extract 235 mg
Asiaticoside content 94 mg
Bromelain 198 mg
Melilot dry extract 153 mg
Coumarin content 30 mg

References:

  1. Yuan D, Mori J, Komatsu KI, Makino T, Kano Y. An anti-aldosteronic diuretic component (drain dampness) in Polyporus sclerotium. Biol Pharm Bull. 2004 27(6):867-70
  2. The Pharmacological Pote ntial of Mushrooms Ulrike Lindequist, Timo H. J. Niedermeyer, and Wolf-Dieter Jülich. Evid. Based Complement. Altern. Med., Sep 2005; 2: 285 – 299
  3. Bioactivity-directed isolation, identification of diuretic compounds from Polyporus umbellatus. Zhao Y.Y, Xie R.M, Chao X, Zhang Y, Lin RC, Sun W.J. J Ethnopharmacol.2009;126(1):184-7
  4. Diuretic activity and kidney medulla AQP1, AQP2, AQP3, V(2)R expression of the aqueous extract of sclerotia ofsclerotia of Polyporus umbellatus FRIES in normal rats. Zhang G, Zeng X, Han L, Wei J.A, Huang H. J Ethnopharmacol. 2010 Epub
  5. Incandela L, Cesarone MR, Cacchio M, De Sanctis MT, Santavenere C, D’Auro MG, Bucci M, Belcaro G.Total triterpenic fraction of Centella asiatica in chronic venous insufficiency and in high-perfusion microangiopathy. Angiology. 2001 Oct; 52 Suppl 2:S9-13)
  6. (Cesarone MR, Laurora G, De Sanctis MT, Belcaro G. Activity of Centella asiatica in venous insufficiency. Minerva Cardioangiol 1992; 40: 137-43)
  7. Cesarone MR, Laurora G, De Sanctis MT, Incandela L, Grimaldi R, Marelli C, Belcaro G. The microcirculatory activity of Centella asiatica in venous insufficiency. A double-blind study. Minerva Cardioangiol 1994; 42: 299-304)
  8. Incandela L, Belcaro G, De Sanctis MT, Cesarone MR, Griffin M, Ippolito E, Bucci M, Cacchio M. Total triterpenic fraction of Centella asiatica in the treatment of venous hypertension: a clinical, prospective, randomized trial using a combined microcirculatory model. Angiology. 2001 Oct; 52 Suppl 2:S61-7)
  9. Incandela L, Belcaro G, De Sanctis MT, Cesarone MR, Griffin M, Ippolito E, Bucci M, Cacchio M. Total triterpenic fraction of Centella asiatica in the treatment of venous hypertension: a clinical, prospective, randomized trial using a combined microcirculatory model. Angiology. 2001 Oct; 52 Suppl 2:S61-7). • Belcaro GV, Grimaldi R, Guidi G. Improvement of capillary permeability in patients with venous hypertension after treatment with TTFCA. Angiology 1990; 41: 533-40)
  10. Arpaia MR, Ferrone R, Amitrano M, Nappo C, Leonardo G, del Guercio R. Effects of Centella asiatica extract on mucopolysaccharide metabolism insubjects with varicose veins. Int J Clin Pharmacol Res 1990; 10: 229-33)
  11. Montecchio GP, Samaden A, Carbone S, Vigotti M, Siragusa S, Piovella F. Centella Asiatica Triterpenic Fraction (CATTF) reduces the number of circulating endothelial cells in subjects with post phlebitic syndrome. Haematologica 1991; 76: 256-9)
  12. Kim YN, Park YS, Kim HK, Jeon BC, Youn SE, Lee HY. Enhancement of the attachment on microcarriers and tPA production by fibroblast cells in a serum-free medium by the addition of the extracts of Centella asiatica. Phytotechnology 1993; 13: 221-6)
  13. Bonte F, Dumas M, Chaudagne C, Meybeck A. Influence of asiatic acid, madecassic acid, and asiaticoside on human collagen I synthesis. Planta Med 1994; 60: 133-5)
  14. Maquart FX, Bellon G, Gillery P, Wegrowski Y, Borel JP. Stimulation of collagen synthesis in fibroblast cultures by a triterpene extracted from Centella asiatica. Connect Tissue Res 1990; 24: 107-20). • Bonte F, Dumas M, Chaudagne C, Meybeck A. Comparativeactivity of asiaticoside and madecassoside on type I and III collagen synthesis by cultured human fibroblasts. Ann Pharm Fr 1995; 53: 38-42
  15. Walker AF, Bundy R, Hicks SM, Middleton RW. Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults. Phytomedicine 2002;9:681-6
  16. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203
  17. Stone MB, Merrick MA, Ingersoll CD, et al. Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management. Clin J Sport Med 2002;12:373-8. • Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8
  18. Hale LP, Greer PK, Sempowski GD. Bromelain treatment alters leukocyte expression of cell surface molecules involved in cellular adhesion and activation. Clin Immunol 2002;104:183-90
  19. Kane S, Goldberg MJ. Use of bromelain for mild ulcerative colitis. Ann Intern Med 2000;132:680. Klein G, Kullich W. Short-term treatment of painful osteoarthritis of the knee with oral enzymes. Clin Drug Invest 2000;19:15-23
  20. Last JA. Hemorrhagic Sweet Clover Disease, Dicumarol, and Warfarin: the Work of Karl Paul Link. J. Biol. Chem. (2005) 280(8): e5 Kresge N, Simoni RD Hill RL. Hemorrhagic Sweet Clover Disease, Dicumarol, and Warfarin: the Work of Karl Paul Link. J. Biol. Chem. (2005) 280(8): e5
  21. Campbell, H. A., and Link, K. P. Studies on the Hemorrhagic Sweet Clover Disease. IV. The Isolation and Crystallization of the Hemorrhagic Agent ( 1941) J. Biol. Chem. 138, 21–33) • Stahmann, M. A., Huebner, C. F., and Link, K. P. Studies on the Hemorrhagic Sweet Clover Disease. V. Identification and Synthesis of the Hemorrhagic Agent (1941) J. Biol. Chem. 138, 513-527)
  22. Overman, R. S., Stahmann, M. A., Huebner, C. F., Sullivan, W. R., Spero, L., Doherty, D. G., Ikawa, M., Graf, L., Roseman, S., and Link, K. P. Studies on the Hemorrhagic Sweet Clover Disease. XIII. Anticoagulant Activity and Structure in the 4-Hydroxycoumarin Group (1944) J. Biol. Chem. 153, 5–24

For further information visit: www.micotherapy.it